For our 8th annual study of STI rates, using the latest data published by the Centers for Disease Control and Prevention (CDC), Innerbody Research analyzed statistics on a city-by-city basis and developed our list of the Top 100 metropolitan areas with the highest STI rates. In this year's report, the metro area with the highest overall STI rate was Detroit, MI, overtaking Philadelphia, PA, which moved to 2nd. Memphis, TN, which had formerly been ranked 2nd, improved to 4th this year, while the metro area that came in 3rd last year — Jackson, MS — improved to 12th in 2025. At the same time, Montgomery, AL (formerly ranked 7th) worsened to 3rd.
3. Montgomery, AL
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